Serum Epidermal Growth Factor Level and its Relation to Severity of Alopecia Areata

Document Type : Original Article


1 Department of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt

2 Department of Dermatology, Mansoura Dermatology Hospital, Mansoura, Egypt

3 Department of Clinical, and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

4 Department of Dermatology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt


 Background: Epidermal growth factor (EGF) is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to epidermal growth factor receptor (EGFR). The roles of EGF and EGFR in the pathogenesis of alopecia areata (AA) are uncertain. However, several reports suggest an association between EGF signaling and AA.
Objective: To estimate the serum level of EGF in patients with Alopecia Areata and its correlation with disease severity.
Patients and Methods: This is a case-control study, was conducted at the outpatient clinic in Beni-Suef University Hospital, on Sixty persons divided into 2 groups: (Group A): included 30 patients having alopecia areata, (Group B): included 30 apparently healthy age- and sex-matched individuals as controls, from January 2020 to July 2022.
Results: There was a strong correlation between EGF and SALT scores with high significance.
Conclusion: The EGF is significantly elevated in AA patients compared to the control subjects. It is also positively correlated with the disease's number and extent, making it a possible marker of AA severity. High levels of EGF are present in patients with AA and positively correlate with severity, which may indicate a causal role of EGF in the pathogenesis of AA. 


Main Subjects