Pharmacological insights into modified citrus pectin: A promising therapeutic potential with anticancer effect

Document Type : Review Article

Authors

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt

Abstract

Modified citrus pectin (MCP) is a naturally soluble dietary fiber derived from citrus pectin that inhibits galectin-3 (Gal-3), a proinflammatory, profibrotic, and pro-metastatic regulatory protein. Interestingly, the anticancer activity of MCP against multiple cancers, such as colon, prostate, urinary bladder, hemangiosarcoma, and breast cancers, has been demonstrated. It could be attributed to its inhibitory effect on cancer cell growth, prevention of metastasis, and induction of cancer cell apoptosis. In addition, MCP presented protective effects against organ damage in different disease models, including cardioprotective, neuroprotective, renoprotective, and hepatoprotective effects. This could be ascribed to its antioxidant, anti-inflammatory, anti-apoptotic, and antifibrotic effects. Further, immunomodulatory, detoxifying, antimicrobial, and chondroprotective effects have also been demonstrated with MCP. It is available in the market as a regarded safe dietary supplement due to its health-promoting effects. This review involves the interplay between cancer, Gal-3, and MCP, as well as the beneficial impacts of MCP in several models of organ damage.

Keywords

Main Subjects

Files

Share

How to cite

Statistics